Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

Recent advances in molecular engineering and synthetic biology provide biomolecular and
cell-based therapies with a high degree of molecular specificity, but limited spatiotemporal …

Over the past decades, considerable attention has been dedicated to the exploitation of
diverse immune cells as therapeutic and/or diagnostic cell‐based microrobots for hard‐to …

Synthetic receptors targeted to the secretory pathway often fail to exhibit the expected
activity due to post-translational modifications (PTMs) and/or improper folding. Here, we …

By the emergence of recombinant DNA technology, many antibody fragments have been
developed devoid of undesired properties of natural immunoglobulins. Among them …

One of the significant challenges remaining in the field of drug delivery is insufficient
targeting of diseased tissues or cells. While efforts to perform targeted drug delivery by …

Cell therapy approaches that employ engineered mammalian cells for on-demand
production of therapeutic agents in the patient's body are moving beyond proof-of-concept in …

Cellular therapies remain constrained by the limited availability of sensors for disease
markers. Here we present an integrated target-to-receptor pipeline for constructing a …