Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

The use of human derived induced pluripotent stem cells (hiPSCs) differentiated to
dopaminergic (DA) neurons offers a valuable experimental model to decorticate the cellular …

Induced pluripotent stem cell (iPSC) technology enabled the production of pluripotent stem
cell lines from somatic cells from a range of known genetic backgrounds. Their ability to …

Tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of
tau, a microtubule-associated protein encoded by MAPT. MAPT expression is near absent in …

NGN2-driven induced pluripotent stem cell (iPSC)-to-neuron conversion is a popular
method for human neurological disease modeling. In this study, we present a standardized …

MUNC18-1 is an essential protein of the regulated secretion machinery. De novo,
heterozygous mutations in STXBP1, the human gene encoding this protein, lead to a severe …

Generation of functional human dopaminergic (DA) neurons from human induced
pluripotent stem cells (hiPSCs) is a crucial tool for modeling dopamine-related human …

Tau pathology is a major hallmark of many neurodegenerative diseases summarized under
the term tauopathies. In most of these disorders, such as Alzheimer's disease, the neuronal …

In neurons, patterns of different microtubule types are essential for neurite extension and
nucleokinesis. Cellular model systems such as rodent primary cultures and induced …

Neurogenin 2 encodes a neural-specific transcription factor (NGN2) able to drive neuronal
fate on somatic and stem cells. NGN2 is expressed in neural progenitors within the …