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Targeting ferroptosis opens new avenues for the development of novel therapeutics
S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities
R Miao, X Fang, Y Zhang, J Wei, Y Zhang, J Tian - Cell death & disease, 2023 - nature.com
The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …
body of evidence suggests that iron imbalance is a key factor in the development of several …
Iron imbalance in neurodegeneration
Iron is an essential element for the development and functionality of the brain, and
anomalies in its distribution and concentration in brain tissue have been found to be …
anomalies in its distribution and concentration in brain tissue have been found to be …
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
Fighting age-related orthopedic diseases: focusing on ferroptosis
Q Ru, Y Li, W **e, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
On iron metabolism and its regulation
ACS Vogt, T Arsiwala, M Mohsen, M Vogel… - International journal of …, 2021 - mdpi.com
Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …
Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis
X Fang, Z Cai, H Wang, D Han, Q Cheng… - Circulation …, 2020 - ahajournals.org
Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron
deficiency and iron overload are associated with cardiomyopathy and heart failure via …
deficiency and iron overload are associated with cardiomyopathy and heart failure via …
Ironing out the details of ferroptosis
DD Zhang - Nature Cell Biology, 2024 - nature.com
Ferroptosis, spurred by excess labile iron and lipid peroxidation, is implicated in various
diseases. Advances have been made in comprehending the lipid-peroxidation side of …
diseases. Advances have been made in comprehending the lipid-peroxidation side of …
Iron metabolism and iron disorders revisited in the hepcidin era
C Camaschella, A Nai, L Silvestri - Haematologica, 2020 - pmc.ncbi.nlm.nih.gov
Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …
Ferroptosis nanomedicine: clinical challenges and opportunities for modulating tumor metabolic and immunological landscape
H Yang, X Yao, Y Liu, X Shen, M Li, Z Luo - Acs Nano, 2023 - ACS Publications
Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …