Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms
This paper reviews various enhanced conformational sampling methods and explicit/implicit
solvent/membrane models, as well as their recent applications to the exploration of the …
solvent/membrane models, as well as their recent applications to the exploration of the …
Scaling protein–water interactions in the martini 3 coarse-grained force field to simulate transmembrane helix dimers in different lipid environments
Martini 3, the latest version of the widely used Martini force field for coarse-grained
molecular dynamics simulations, is a promising tool to investigate proteins in phospholipid …
molecular dynamics simulations, is a promising tool to investigate proteins in phospholipid …
[HTML][HTML] Helix-helix interactions in membrane domains of bitopic proteins: Specificity and role of lipid environment
Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …
[HTML][HTML] Hydrogen Bond Strengthens Acceptor Group: The Curious Case of the C–H··· O= C Bond
An H-bond involves the sharing of a hydrogen atom between an electronegative atom to
which it is covalently bound (the donor) and another electronegative atom serving as an …
which it is covalently bound (the donor) and another electronegative atom serving as an …
Heteromeric solute carriers: function, structure, pathology and pharmacology
SJ Fairweather, N Shah, S Brӧer - Protein Reviews: Volume 21, 2021 - Springer
Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …
and include uniporters, exchangers and symporters. Following several decades of …
Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis
The Bcl-2 protein family comprises both pro-and antiapoptotic members that control the
permeabilization of the mitochondrial outer membrane, a crucial step in the modulation of …
permeabilization of the mitochondrial outer membrane, a crucial step in the modulation of …
Fake it 'till you make it—the pursuit of suitable membrane mimetics for membrane protein biophysics
Membrane proteins evolved to reside in the hydrophobic lipid bilayers of cellular
membranes. Therefore, membrane proteins bridge the different aqueous compartments …
membranes. Therefore, membrane proteins bridge the different aqueous compartments …
Lipid concentration and molar ratio boundaries for the use of isotropic bicelles
M Beaugrand, AA Arnold, J Hénin, DE Warschawski… - Langmuir, 2014 - ACS Publications
Bicelles are model membranes generally made of long-chain
dimyristoylphosphatidylcholine (DMPC) and short-chain dihexanoyl-PC (DHPC). They are …
dimyristoylphosphatidylcholine (DMPC) and short-chain dihexanoyl-PC (DHPC). They are …
HER2 transmembrane domain dimerization coupled with self-association of membrane-embedded cytoplasmic juxtamembrane regions
Receptor tyrosine kinases of the human epidermal growth factor receptor (HER or ErbB)
family transduce biochemical signals across plasma membrane, playing a significant role in …
family transduce biochemical signals across plasma membrane, playing a significant role in …