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The chemical biology of naphthoquinones and its environmental implications
Y Kumagai, Y Shinkai, T Miura… - Annual review of …, 2012 - annualreviews.org
Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …
Cdc25 phosphatases and cancer
The Cdc25 phosphatases function as key regulators of the cell cycle during normal
eukaryotic cell division and as mediators of the checkpoint response in cells with DNA …
eukaryotic cell division and as mediators of the checkpoint response in cells with DNA …
Therapeutic targeting the cell division cycle 25 (CDC25) phosphatases in human acute myeloid leukemia—the possibility to target several kinases through inhibition …
The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C.
These three molecules are important regulators of several steps in the cell cycle, including …
These three molecules are important regulators of several steps in the cell cycle, including …
Site-specific binding of quinones to proteins through thiol addition and addition− elimination reactions
Ubiquinone-0, menaquinone-0, and 2, 3, 5-trimethyl-1, 4-benzoquinone were site-
specifically bound to free cysteine of proteins (yeast iso-1 cytochrome c as a model protein) …
specifically bound to free cysteine of proteins (yeast iso-1 cytochrome c as a model protein) …
Drug discovery and protein tyrosine phosphatases
Protein tyrosine phosphatases (PTPs) play a critical role in physiological signaling pathways
by controlling the level of tyrosine phosphorylation. The past decade has seen a vast …
by controlling the level of tyrosine phosphorylation. The past decade has seen a vast …
Chemical knockdown of protein-tyrosine phosphatase 1B by 1, 2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth …
N Iwamoto, D Sumi, T Ishii, K Uchida, AK Cho… - Journal of Biological …, 2007 - jbc.org
1, 2-Naphthoquinone (1, 2-NQ), an atmospheric contaminant, causes the contraction of
guinea pig trachea through the activation of epidermal growth factor receptor (EGFR) by …
guinea pig trachea through the activation of epidermal growth factor receptor (EGFR) by …
Small-molecule inhibitors of SETD8 with cellular activity
SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to
monomethylate lysine 20 of histone H4 in vivo. SETD8's methyltransferase activity has been …
monomethylate lysine 20 of histone H4 in vivo. SETD8's methyltransferase activity has been …
Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease
▪ Abstract The complete sequencing of the human genome is generating many novel targets
for drug discovery. Understanding the pathophysiological roles of these putative targets and …
for drug discovery. Understanding the pathophysiological roles of these putative targets and …
Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp.
S Cao, C Foster, M Brisson, JS Lazo… - Bioorganic & medicinal …, 2005 - Elsevier
Separation of an extract of a Xestospongia sp., guided by bioassay against Cdc25B, led to
the isolation of nine compounds, halenaquinone (1), xestoquinone (2), adociaquinones A …
the isolation of nine compounds, halenaquinone (1), xestoquinone (2), adociaquinones A …
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity
MP Brun, E Braud, D Angotti, O Mondésert… - Bioorganic & medicinal …, 2005 - Elsevier
CDC25 dual-specificity phosphatases are essential key regulators of eukaryotic cell cycle
progression and the CDC25A and B isoforms are over-expressed in different tumors and …
progression and the CDC25A and B isoforms are over-expressed in different tumors and …