Mouse models of allergic asthma: acute and chronic allergen challenge
AT Nials, S Uddin - Disease models & mechanisms, 2008 - journals.biologists.com
Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying
physiological and immunological processes are not fully understood. Animal models have …
physiological and immunological processes are not fully understood. Animal models have …
Modeling TH2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma
In this review, we highlight experiments conducted in our laboratories that have elucidated
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease
Allergic asthma is an inflammatory disease of the lung characterized by abnormal T helper-2
(TH2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to the …
(TH2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to the …
Inhibition of house dust mite–induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment
Background Glucocorticoids are used as mainstay therapy for asthma, but some patients
remain resistant to therapy. MicroRNAs (miRNAs) are important regulators of the immune …
remain resistant to therapy. MicroRNAs (miRNAs) are important regulators of the immune …
Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment
DL Burke, MG Frid, CL Kunrath… - … of Physiology-Lung …, 2009 - journals.physiology.org
Recent studies demonstrate that sustained hypoxia induces the robust accumulation of
leukocytes and mesenchymal progenitor cells in pulmonary arteries (PAs). Since the factors …
leukocytes and mesenchymal progenitor cells in pulmonary arteries (PAs). Since the factors …
Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target
Background The role of microRNAs (miRNAs) in regulating gene expression is currently an
area of intense interest. Relatively little is known, however, about the role of miRNAs in …
area of intense interest. Relatively little is known, however, about the role of miRNAs in …
The role of lymphocytes in radiotherapy-induced adverse late effects in the lung
F Wirsdörfer, V Jendrossek - Frontiers in immunology, 2016 - frontiersin.org
Radiation-induced pneumonitis and fibrosis are dose-limiting side effects of thoracic
irradiation. Thoracic irradiation triggers acute and chronic environmental lung changes that …
irradiation. Thoracic irradiation triggers acute and chronic environmental lung changes that …
Interleukin-17 as a drug target in human disease
S Ivanov, A Lindén - Trends in Pharmacological Sciences, 2009 - cell.com
Interleukin (IL)-17 (now synonymous with IL-17A) is an archetype molecule for an entire
family of IL-17 cytokines. Currently believed to be produced mainly by a specific subset of …
family of IL-17 cytokines. Currently believed to be produced mainly by a specific subset of …
Interleukin-17 regulation: an attractive therapeutic approach for asthma
SJ Park, YC Lee - Respiratory research, 2010 - Springer
Abstract Interleukin (IL)-17 is recognized to play a critical role in numerous immune and
inflammatory responses by regulating the expression of various inflammatory mediators …
inflammatory responses by regulating the expression of various inflammatory mediators …
Corticosteroid resistance in asthma: Cellular and molecular mechanisms
Inhaled glucocorticoids (GCs) are drugs widely used as treatment for asthma patients. They
prevent the recruitment and activation of lung immune and inflammatory cells and …
prevent the recruitment and activation of lung immune and inflammatory cells and …