The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Skeletal development is a complex process which requires the tight regulation of gene
activation and suppression in response to local signaling pathways. Among these pathways …

Podocyte injury is an early event in diabetic kidney disease and is a hallmark of
glomerulopathy. MicroRNA-146a (miR-146a) is highly expressed in many cell types under …

Over a decade ago, it was proposed that the regulation of tubular repair in the kidney might
involve the recapitulation of developmental pathways. Although the kidney cannot generate …

Background Live imaging provides an essential methodology for understanding complex
and dynamic cell behaviors and their underlying molecular mechanisms. Genetically …

Podocytopathy is the most common feature of glomerular disorder characterized by
podocyte injury-or dysfunction-induced excessive proteinuria, which ultimately develops into …

Acute kidney injury (AKI) is a challenging side effect which may clinically impede the use of
gentamicin (GM). The present study explored the impact of liraglutide (Lir) on GM-induced …

Background Notch1 signalling is a stem-cell-related pathway that is essential for embryonic
development, tissue regeneration and organogenesis. However, the role of Notch1 in the …

MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that modulate
diverse biological processes predominantly by translation inhibition or induction of mRNA …