Host–parasite co-evolution and its genomic signature
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
Understanding the evolution of immune genes in jawed vertebrates
Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize
defence against pathogens within a given environment. Recent advances in genetics …
defence against pathogens within a given environment. Recent advances in genetics …
Long-term balancing selection for pathogen resistance maintains trans-species polymorphisms in a planktonic crustacean
Balancing selection is an evolutionary process that maintains genetic polymorphisms at
selected loci and strongly reduces the likelihood of allele fixation. When allelic …
selected loci and strongly reduces the likelihood of allele fixation. When allelic …
The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope
Abstract The HLA-DRB1* 03: 01 allele is a major genetic risk factor in systemic lupus
erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show …
erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show …
Gasdermin and gasdermin-like pore-forming proteins in invertebrates, fungi and bacteria
The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key
molecular players controlling immune-related cell death in mammals. Characterized …
molecular players controlling immune-related cell death in mammals. Characterized …
Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen
Red Queen host–parasite co-evolution can drive adaptations of immune genes by positive
selection that erodes genetic variation (Red Queen arms race) or results in a balanced …
selection that erodes genetic variation (Red Queen arms race) or results in a balanced …
Gene expression variability in human and chimpanzee populations share common determinants
Inter-individual variation in gene expression has been shown to be heritable and is often
associated with differences in disease susceptibility between individuals. Many studies …
associated with differences in disease susceptibility between individuals. Many studies …
Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction
J Balanta‐Melo, MA Torres‐Quintana… - Journal of oral …, 2019 - Wiley Online Library
Background Masseter muscle function influences mandibular bone homeostasis. As
previously reported, bone resorption markers increased in the mouse mandibular condyle …
previously reported, bone resorption markers increased in the mouse mandibular condyle …
Microbial gasdermins: More than a billion years of pyroptotic-like cell death
Q Zheng, A Daskalov - Seminars in immunology, 2023 - Elsevier
In the recent past, the concept of immunity has been extended to eukaryotic and prokaryotic
microorganisms, like fungi and bacteria. The latest findings have drawn remarkable …
microorganisms, like fungi and bacteria. The latest findings have drawn remarkable …
Diversifying selection and climatic effects on major histocompatibility complex class II gene diversity in the greater horseshoe bat
X Li, T Liu, A Li, Y **ao, K Sun… - Evolutionary …, 2023 - Wiley Online Library
Heterogeneous pathogenic stress can shape major histocompatibility complex (MHC)
diversity by influencing the functional plasticity of the immune response. Therefore, MHC …
diversity by influencing the functional plasticity of the immune response. Therefore, MHC …