The future of intensive care: delirium should no longer be an issue

K Kotfis, I van Diem-Zaal, S Williams Roberson… - Critical Care, 2022 - Springer
In the ideal intensive care unit (ICU) of the future, all patients are free from delirium, a
syndrome of brain dysfunction frequently observed in critical illness and associated with …

Neurological complications of sepsis

S Piva, M Bertoni, N Gitti, FA Rasulo… - Current Opinion in …, 2023 - journals.lww.com
Neurological complications of sepsis : Current Opinion in Critical Care Neurological
complications of sepsis : Current Opinion in Critical Care Log in or Register Subscribe to …

A world-wide study on delirium assessments and presence of protocols

P Nydahl, K Liu, G Bellelli, J Benbenishty… - Age and …, 2024 - academic.oup.com
Background Delirium is a common complication of older people in hospitals, rehabilitation
and long-term facilities. Objective To assess the worldwide use of validated delirium …

Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline

MH Møller, W Alhazzani, K Lewis, E Belley-Cote… - Intensive care …, 2022 - Springer
Purpose The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM‑RPG) was
to formulate evidence‑based guidance for the use of dexmedetomidine for sedation in …

Pharmacologic prophylaxis of postoperative delirium in elderly patients: a network meta-analysis of randomized controlled trials

TH Liu, YT Lin, JY Wu, PY Huang, WW Tsai… - Journal of Psychiatric …, 2025 - Elsevier
Background The high incidence and mortality rates of postoperative delirium (POD) among
elderly patients highlights the pressing need for tailored prophylactic strategies. Despite …

A pharmacogenetic precision medicine approach to analgesia and sedation optimization in critically ill adults

AL Dzierba, JL Stollings… - … : The Journal of Human …, 2023 - Wiley Online Library
Precision medicine is a growing field in critical care. Research increasingly demonstrated
pharmacogenomic variability to be an important determinant of analgesic and sedative drug …

A comparation of dexmedetomidine and midazolam for sedation in patients with mechanical ventilation in ICU: A systematic review and meta-analysis

J Wen, X Ding, C Liu, W Jiang, Y Xu, X Wei, X Liu - Plos one, 2023 - journals.plos.org
Background The use of dexmedetomidine rather than midazolam may improve ICU
outcomes. We summarized the available recent evidence to further verify this conclusion …

Intensive care unit delirium—a decade of learning

K Kotfis, EW Ely, Y Shehabi - The Lancet Respiratory Medicine, 2023 - thelancet.com
Think of delirium as the phenotypic manifestation of global, acute brain dysfunction that can
deprive patients of their dignity. This syndrome of acute changes in awareness, attention …

Sedation and shivering management after cardiac arrest

BJ Geller, CB Maciel, TL May… - European Heart Journal …, 2023 - academic.oup.com
Management of sedation and shivering during targeted temperature management (TTM)
after cardiac arrest is limited by a dearth of high-quality evidence to guide clinicians. Data …

Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway

Q Zhao, C Kong, X Wu, Y Ling, J Shi, S Li, Y Zhu… - BMC Pulmonary …, 2024 - Springer
Background Patients who suffered from sepsis-induced acute lung injury (ALI) always need
sedation for mechanical ventilation in intensive care unit (ICU). Ciprofol (Cip), a novel …