Mendelian randomization

E Sanderson, MM Glymour, MV Holmes… - Nature Reviews …, 2022 - nature.com
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Mendelian randomization: concepts and scope

RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Guidelines for performing Mendelian randomization investigations: update for summer 2023

S Burgess, GD Smith, NM Davies… - Wellcome open …, 2023 - pmc.ncbi.nlm.nih.gov
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

The associations between modifiable risk factors and nonalcoholic fatty liver disease: A comprehensive Mendelian randomization study

J **e, H Huang, Z Liu, Y Li, C Yu, L Xu, C Xu - Hepatology, 2023 - journals.lww.com
Conclusions: Genetically predicted alcohol frequency, elevated serum liver enzymes, poor
physical condition, obesity traits, T2DM, and hypertension were associated with an …

[HTML][HTML] Statistical methods for Mendelian randomization in genome-wide association studies: a review

FJ Boehm, X Zhou - Computational and structural biotechnology journal, 2022 - Elsevier
Genome-wide association studies have yielded thousands of associations for many
common diseases and disease-related complex traits. The identified associations made it …

[КНИГА][B] Mendelian randomization: methods for causal inference using genetic variants

S Burgess, SG Thompson - 2021 - books.google.com
Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Sociology, genetics, and the coming of age of sociogenomics

MC Mills, FC Tropf - Annual review of sociology, 2020 - annualreviews.org
Recent years have seen the birth of sociogenomics via the infusion of molecular genetic
data. We chronicle the history of genetics, focusing particularly on post-2005 genome-wide …

Zhang j

J Zhang, J Wu, J Yu - Yang B. Wu C. Cyclosporua A, 2017 - bmjopen.bmj.com
1 62.96 31.48 31.94 64.81 31.94 44.44 2 B 2 75.93 72.22 63.89 68.52 66.67 75.00 6 A 3
74.07 81.48 77.08 55.56 72.22 69.44 5 B 4 38.89 33.33 30.56 61.11 41.67 61.11 2 B 5 …

Association of gut microbiome and primary liver cancer: A two‐sample Mendelian randomization and case–control study

J Ma, J Li, C **, J Yang, C Zheng, K Chen… - Liver …, 2023 - Wiley Online Library
Abstract Background and Aims Observational epidemiology studies suggested a
relationship between the gut microbiome and primary liver cancer. However, the causal …

Understanding the assumptions underlying Mendelian randomization

C de Leeuw, J Savage, IG Bucur, T Heskes… - European Journal of …, 2022 - nature.com
With the rapidly increasing availability of large genetic data sets in recent years, Mendelian
Randomization (MR) has quickly gained popularity as a novel secondary analysis method …