BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

The glutathione transferases (GSTs) are one of the most important families of detoxifying
enzymes in nature. The classic activity of the GSTs is conjugation of compounds with …

The nuclear receptor peroxisome proliferator–activated receptor-γ (PPARγ) has important
roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate …

Sulfonamide derivatives exhibit a wide biological activity and can function as potential
medical molecules in the development of a drug. Studies have reported that the compounds …

A rationally designed Pt (IV) anticancer compound is described, employing the novel
concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt …

Glutathione transferases (GSTs) are important detoxifying enzymes that catalyze the
conjugation of electrophilic substrates to glutathione. In recent years, GSTs have been of …

Naturally-occurring and synthetic chalcone compounds have shown promising biological
activity and safety profiles and have the potential to be developed as, or more properly …

Cancer is a serious problem affecting the health of all human societies. Chemotherapy
refers to the use of drugs to kill cancer or the origin of cancer. In the past three decades …

In general, glutathione conjugation is regarded as a detoxication reaction. However,
depending on the properties of the substrate, bioactivation is also possible. Four types of …

Many transition metal complexes have unique physicochemical properties that can be
efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double …