Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

There is considerable heterogeneity in the cardiometabolic abnormalities associated with
obesity. We evaluated multi-organ system metabolic function in 20 adults with metabolically …

Appreciation of the importance of Akkermansia muciniphila is growing, and it is becoming
increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD).
During the past 50 years, there has been an dramatic increase in life expectancy with a …

Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

High‐intensity interval training (HIIT) is characterised by short bouts of high‐intensity
submaximal exercise interspersed with rest periods. Low‐volume HIIT, typically involving …

Ferrucci et al Time and the Metrics of Aging 741 disease, and all-cause mortality, although
the causal nature of these associations and whether telomere shortening affects the aging …