Introduction The most prevalent biological macromolecules in living systems are proteins,
the building block of life, extremely dynamic in structure and functions. Due to several …

Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …

Background Smoking remains one of the leading preventable causes of death. Smoking
leaves a strong signature on the blood methylome as shown in multiple studies using the …

Gastric cancer is the abnormal growth of stomach cells. The symptoms of this disease
include difficulty in swallowing, heartburn, stomach pain, indigestion, nausea, vomiting, and …

Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on
tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the …

Introduction: This review explores insights provided by next-generation sequencing (NGS) of
pituitary tumors and the clinical implications. Areas covered: Although syndromic forms …

Non–small lung cancer (NSCLC) is a common malignant disease with very poor outcome.
Accurate prediction of prognosis can better guide patient risk stratification and treatment …

Abstract Cadherin-23 (CDH23) mediates homotypic and heterotypic cell-cell adhesions in
cancer cells. However, the epigenetic regulation, the biological functions, the mechanisms …

There is a paucity of adequate mouse models and cell lines available to study lung
squamous cell carcinoma (LUSC). We have generated and characterized two models of …

Cadherin‐23, a giant atypical cadherin, form homophilic interactions at the cell–cell junction
of epithelial cells and heterophilic interactions with protocadherin‐15 at the tip links of …