Noradrenergic Locus Coeruleus pathways in pain modulation
The noradrenergic system is crucial for several activities in the body, including the
modulation of pain. As the major producer of noradrenaline (NA) in the central nervous …
modulation of pain. As the major producer of noradrenaline (NA) in the central nervous …
Reticular formation and pain: the past and the future
I Martins, I Tavares - Frontiers in neuroanatomy, 2017 - frontiersin.org
The involvement of the reticular formation (RF) in the transmission and modulation of
nociceptive information has been extensively studied. The brainstem RF contains several …
nociceptive information has been extensively studied. The brainstem RF contains several …
Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons
There is strong comorbidity between chronic pain and depression, although the neural
circuits and mechanisms underlying this association remain unclear. By combining …
circuits and mechanisms underlying this association remain unclear. By combining …
Angiotensin II type 2 receptor (AT2R) localization and antagonist‐mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory …
U Anand, P Facer, Y Yiangou, M Sinisi… - … journal of pain, 2013 - Wiley Online Library
Abstract Background The angiotensin II (AngII) receptor subtype 2 (AT2R) is expressed in
sensory neurons and may play a role in nociception and neuronal regeneration. Methods …
sensory neurons and may play a role in nociception and neuronal regeneration. Methods …
Renin–angiotensin system in pain: existing in a double life?
Apart from the well-documented role of the renin–angiotensin–aldosterone system (RAAS)
in regulating the blood pressure and other related parameters, its role in modulating different …
in regulating the blood pressure and other related parameters, its role in modulating different …
[PDF][PDF] Increased noradrenergic neurotransmission to a pain facilitatory area of the brain is implicated in facilitation of chronic pain
I Martins, P Carvalho, MG de Vries, A Teixeira-Pinto… - …, 2015 - academia.edu
Background: Noradrenaline reuptake inhibitors are known to produce analgesia through a
spinal action but they also act in the brain. However, the action of noradrenaline on …
spinal action but they also act in the brain. However, the action of noradrenaline on …
Angiotensin-related peptides and their role in pain regulation
W Nemoto, R Yamagata, O Nakagawasai, K Tan-No - Biology, 2023 - mdpi.com
Simple Summary Evidence indicates that angiotensin (Ang)-related peptides, also known as
hypertensive peptides, are involved in pain regulation. Ang-related peptides exhibit various …
hypertensive peptides, are involved in pain regulation. Ang-related peptides exhibit various …
Response properties of nociceptive neurons in the caudal ventrolateral medulla (CVLM) in monoarthritic and healthy control rats: modulation of responses by the …
We characterized response properties of neurons in the caudal ventrolateral medulla
(CVLM), a structure involved in pain modulation. Electrophysiological recordings were …
(CVLM), a structure involved in pain modulation. Electrophysiological recordings were …
Angiotensin-(1–7) induces peripheral antinociception through mas receptor activation in an opioid-independent pathway
ACO Costa, LK Becker, ÉR Moraes, TRL Romero… - Pharmacology, 2012 - karger.com
The G protein-coupled receptor Mas was recently described as an angiotensin-(1–7)[Ang-(1–
7)] receptor. In the present study, we demonstrate an antinociceptive effect of Ang-(1–7) for …
7)] receptor. In the present study, we demonstrate an antinociceptive effect of Ang-(1–7) for …
Involvement of A5/A7 noradrenergic neurons and B2 serotonergic neurons in nociceptive processing: A fiber photometry study
S Moriya, A Yamashita, D Masukawa… - Neural Regeneration …, 2022 - journals.lww.com
In the central nervous system, the A6 noradrenaline (NA) and the B3 serotonin (5-HT) cell
groups are well-recognized players in the descending antinociceptive system, while other …
groups are well-recognized players in the descending antinociceptive system, while other …