Noradrenergic Locus Coeruleus pathways in pain modulation

M Llorca-Torralba, G Borges, F Neto, JA Mico… - Neuroscience, 2016 - Elsevier
The noradrenergic system is crucial for several activities in the body, including the
modulation of pain. As the major producer of noradrenaline (NA) in the central nervous …

Reticular formation and pain: the past and the future

I Martins, I Tavares - Frontiers in neuroanatomy, 2017 - frontiersin.org
The involvement of the reticular formation (RF) in the transmission and modulation of
nociceptive information has been extensively studied. The brainstem RF contains several …

Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons

M Llorca-Torralba, C Camarena-Delgado… - Brain, 2022 - academic.oup.com
There is strong comorbidity between chronic pain and depression, although the neural
circuits and mechanisms underlying this association remain unclear. By combining …

Angiotensin II type 2 receptor (AT2R) localization and antagonist‐mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory …

U Anand, P Facer, Y Yiangou, M Sinisi… - … journal of pain, 2013 - Wiley Online Library
Abstract Background The angiotensin II (AngII) receptor subtype 2 (AT2R) is expressed in
sensory neurons and may play a role in nociception and neuronal regeneration. Methods …

Renin–angiotensin system in pain: existing in a double life?

A Bali, N Singh, AS Jaggi - Journal of the Renin-Angiotensin …, 2014 - journals.sagepub.com
Apart from the well-documented role of the renin–angiotensin–aldosterone system (RAAS)
in regulating the blood pressure and other related parameters, its role in modulating different …

[PDF][PDF] Increased noradrenergic neurotransmission to a pain facilitatory area of the brain is implicated in facilitation of chronic pain

I Martins, P Carvalho, MG de Vries, A Teixeira-Pinto… - …, 2015 - academia.edu
Background: Noradrenaline reuptake inhibitors are known to produce analgesia through a
spinal action but they also act in the brain. However, the action of noradrenaline on …

Angiotensin-related peptides and their role in pain regulation

W Nemoto, R Yamagata, O Nakagawasai, K Tan-No - Biology, 2023 - mdpi.com
Simple Summary Evidence indicates that angiotensin (Ang)-related peptides, also known as
hypertensive peptides, are involved in pain regulation. Ang-related peptides exhibit various …

Response properties of nociceptive neurons in the caudal ventrolateral medulla (CVLM) in monoarthritic and healthy control rats: modulation of responses by the …

F Pinto-Ribeiro, OB Ansah, A Almeida… - Brain Research …, 2011 - Elsevier
We characterized response properties of neurons in the caudal ventrolateral medulla
(CVLM), a structure involved in pain modulation. Electrophysiological recordings were …

Angiotensin-(1–7) induces peripheral antinociception through mas receptor activation in an opioid-independent pathway

ACO Costa, LK Becker, ÉR Moraes, TRL Romero… - Pharmacology, 2012 - karger.com
The G protein-coupled receptor Mas was recently described as an angiotensin-(1–7)[Ang-(1–
7)] receptor. In the present study, we demonstrate an antinociceptive effect of Ang-(1–7) for …

Involvement of A5/A7 noradrenergic neurons and B2 serotonergic neurons in nociceptive processing: A fiber photometry study

S Moriya, A Yamashita, D Masukawa… - Neural Regeneration …, 2022 - journals.lww.com
In the central nervous system, the A6 noradrenaline (NA) and the B3 serotonin (5-HT) cell
groups are well-recognized players in the descending antinociceptive system, while other …