Monitoring and manipulating the physical and chemical behavior of single molecules is an
important development direction of molecular electronics that aids in understanding the …

Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …

Microfabricated integrated circuits revolutionized computation by vastly reducing the space,
labor, and time required for calculations. Microfluidic systems hold similar promise for the …

Miniaturization can expand the capability of existing bioassays, separation technologies and
chemical synthesis techniques. Although a reduction in size to the micrometre scale will …

Probing non-equilibrium dynamics with single-molecule spectroscopy is important for
dissecting biomolecular mechanisms. However, existing microfluidic rapid-mixing systems …

The application of single-molecule fluorescence techniques to complex biological systems
places demands on the performance of single fluorophores. We present an enzymatic …

Fluorescence arguably constitutes the most widely used experimental approach in the field
of protein folding. Hence, any review of the use of fluorescence to probe protein stability and …

Single-stranded oligonucleotides stabilize highly fluorescent Ag nanoclusters, with emission
colors tunable via DNA sequence. We utilized DNA microarrays to optimize these scaffold …

How fast can a protein possibly fold? This question has stimulated experimentalists to seek
fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the …

Quantum mechanics provides the most accurate microscopic description of the world around
us, yet the interface between quantum mechanics and biology is only now being explored …