Polyglutamine spinocerebellar ataxias—from genes to potential treatments
The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …
neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and …
Post-translational modifications of deubiquitinating enzymes: expanding the ubiquitin code
Y Wang, F Wang - Frontiers in pharmacology, 2021 - frontiersin.org
Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …
several biological processes in eukaryotes. This process could be reversed by …
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
Post-translational modifications: regulators of neurodegenerative proteinopathies
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
Machado–Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy
Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …
(SCA 3), is an incurable disorder, widely regarded as the most common form of …
Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
B Estavoyer, C Messmer, M Echbicheb… - Journal of Biological …, 2022 - ASBMB
Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …
The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF 8
The E3 ubiquitin ligase RNF 8 (RING finger protein 8) is a pivotal enzyme for DNA repair.
However, RNF 8 hyper‐accumulation is tumour‐promoting and positively correlates with …
However, RNF 8 hyper‐accumulation is tumour‐promoting and positively correlates with …
[HTML][HTML] From pathogenesis to novel therapeutics for spinocerebellar ataxia type 3: evading potholes on the way to translation
Abstract Spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …
(MJD), is a neurodegenerative disorder caused by a polyglutamine expansion in the ATXN3 …
Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder
Severe and persistent disruptions to sleep and circadian rhythms are common in people
with opioid use disorder (OUD). Preclinical evidence suggests altered molecular rhythms in …
with opioid use disorder (OUD). Preclinical evidence suggests altered molecular rhythms in …
A survey of protein interactions and posttranslational modifications that influence the polyglutamine diseases
The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …
system. Among the various diseases caused by misfolded proteins is the family of the …