Recently, the incidence of brain diseases, such as central nervous system degenerative
diseases, brain tumors, and cerebrovascular diseases, has increased. However, the blood …

The blood–brain barrier presents a key limitation to the administration of therapeutic
molecules for the treatment of brain disease. While drugs administered orally or …

Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,
abdominal pain, and fluctuations in plasma levels. The purpose of this research was to …

The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome
the challenges associated with conventional drug administration for central nervous system …

Background/objectives: The blood–brain barrier (BBB) significantly limits the treatment of
central nervous system disorders, such as schizophrenia, by restricting drug delivery to the …

Background/Objectives: Parkinson's disease (PD) is a progressive neuro-degenerative
disorder characterized by α-synuclein aggregation, which promotes neuronal death and …

Quetiapine (QP) is a second-generation short-acting antipsychotic drug extensively
metabolized in the liver, producing pharmacologically inactive metabolites and leading to …

Abstract The Prevalence of Depressive and Psychiatric disorders is increasing globally, and
despite the availability of numerous FDA-approved drugs, treatment remains challenging …

The combination of herbal drugs with a topical antibacterial for managing a chronic disease
like acne vulgaris has emerged lately to settle side effects and bacterial multidrug …

Lamotrigine.(LMT) is a triazine drug has an antiepileptic effect but with low water solubility,
dissolution rate and thus therapeutic effect. Spanlastics are nano-vesicular carriers' act as …