Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

Numerous tissue regeneration paradigms show evident neurological dependence, including
mammalian fingertip, skin, and bone regeneration. The mature skeleton is innervated by an …

The mouse genetic revolution has shown repeatedly that most organs have more functions
than expected. This has led to the realization that, in addition to a molecular and cellular …

The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

Leptin originates in adipocytes, including those in bone marrow, and circulates in
concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct …

It is from the discovery of leptin and the central nervous system as a regulator of bone
remodeling that the presence of autonomic nerves within the skeleton transitioned from a …

A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from
osteoblasts to adipocytes contributes to age‐and menopause‐associated bone loss and …

According to Descartes, minds and bodies are distinct kinds of “substance”, and they cannot
have causal interactions. However, in neuroscience, the two-way interaction between the …

Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …