Basophils from allergy to cancer

R Poto, AR Gambardella, G Marone… - Frontiers in …, 2022‏ - frontiersin.org
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating
leukocytes. While this scarcity long hampered basophil studies, innovations during the past …

[HTML][HTML] The role of gut microbiota and leaky gut in the pathogenesis of food allergy

R Poto, W Fusco, E Rinninella, M Cintoni, F Kaitsas… - Nutrients, 2023‏ - mdpi.com
Food allergy (FA) is a growing public health concern, with an increasing prevalence in
Western countries. Increasing evidence suggests that the balance of human gut microbiota …

Mast cells: a novel therapeutic avenue for cardiovascular diseases?

R Poto, G Marone, SJ Galli… - Cardiovascular …, 2024‏ - academic.oup.com
Mast cells are tissue-resident immune cells strategically located in different compartments of
the normal human heart (the myocardium, pericardium, aortic valve, and close to nerves) as …

Antibody-mediated regulation of basophils: emerging views and clinical implications

K Chen, Y Hao, M Guzmán, G Li, A Cerutti - Trends in immunology, 2023‏ - cell.com
An increasing number of human diseases, including allergies, infections, inflammation, and
cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are …

Basophils beyond allergic and parasitic diseases

R Poto, S Loffredo, G Marone, A Di Salvatore… - Frontiers in …, 2023‏ - frontiersin.org
Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing
so, they can rapidly release mediators that are hallmark of allergic disease. This …

[HTML][HTML] Human lung mast cells: therapeutic implications in asthma

R Poto, G Criscuolo, G Marone, CE Brightling… - International Journal of …, 2022‏ - mdpi.com
Mast cells are strategically located in different compartments of the lung in asthmatic
patients. These cells are widely recognized as central effectors and immunomodulators in …

bSRWPSO-FKNN: A boosted PSO with fuzzy K-nearest neighbor classifier for predicting atopic dermatitis disease

Y Li, D Zhao, Z Xu, AA Heidari, H Chen… - Frontiers in …, 2023‏ - frontiersin.org
Introduction Atopic dermatitis (AD) is an allergic disease with extreme itching that bothers
patients. However, diagnosing AD depends on clinicians' subjective judgment, which may …

Inhibition of mast cell degranulation in atopic dermatitis by celastrol through suppressing MRGPRX2

C Yao, W Ye, M Chen - Disease Markers, 2023‏ - Wiley Online Library
Background. Atopic dermatitis is a common dermatological disease, and mast cell
degranulation is believed to be related with the progression of atopic dermatitis. Mas‐related …

[HTML][HTML] A Comparison of Natural and Therapeutic Anti-IgE Antibodies

M Vogel, P Engeroff - Antibodies, 2024‏ - mdpi.com
Immunoglobulin E (IgE) plays a critical role for the immune system, fighting against
parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation …

Mechanism underlying polyvalent IgG-induced regulatory T cell activation and its clinical application: anti-idiotypic regulatory T cell theory for immune tolerance

JR Victor, DH Nahm - Frontiers in Immunology, 2023‏ - frontiersin.org
The regulatory T (Treg) cells constitute a functionally defined subpopulation of T cells that
modulate the immune system and maintain immune tolerance through suppression of the …