Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy
In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …
Tumour hypoxia in driving genomic instability and tumour evolution
A Suvac, J Ashton, RG Bristow - Nature Reviews Cancer, 2025 - nature.com
Intratumour hypoxia is a feature of all heterogenous solid tumours. Increased levels or
subregions of tumour hypoxia are associated with an adverse clinical prognosis, particularly …
subregions of tumour hypoxia are associated with an adverse clinical prognosis, particularly …
Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion
VE Getova, E Orozco-Garcia, S Palmers… - Tissue engineering and …, 2024 - Springer
Abstract Background: The extracellular vesicles (EVs) secreted by adipose tissue-derived
stromal cells (ASC) are microenvironment modulators in tissue regeneration by releasing …
stromal cells (ASC) are microenvironment modulators in tissue regeneration by releasing …
Anti‐angiogenic therapy enhances cancer immunotherapy: Mechanism and clinical application
AQ Li, JH Fang - Interdisciplinary Medicine, 2024 - Wiley Online Library
Immunotherapy, specifically immune checkpoint inhibitors, is revolutionizing cancer
treatment, achieving durable control of previously incurable or advanced tumors. However …
treatment, achieving durable control of previously incurable or advanced tumors. However …
Cancer metabolic reprogramming and precision medicine-current perspective
T Gao, L Yang, Y Zhang, O Ba**ka… - Frontiers in …, 2024 - frontiersin.org
Despite the advanced technologies and global attention on cancer treatment strategies,
cancer continues to claim lives and adversely affects socio-economic development …
cancer continues to claim lives and adversely affects socio-economic development …
Cytoplasmic mRNA cap** enzyme is regulated by hypoxia inducible factor HIF1α and controls stability of the target lncRNAs during hypoxia
S Islam, C Mukherjee - bioRxiv, 2024 - biorxiv.org
Hypoxia-inducible factors (HIFs) regulate the expression of several hypoxia-responsive
RNAs (HRR) to sustain cellular homeostasis. Cytoplasmic pool of mRNA cap** enzyme …
RNAs (HRR) to sustain cellular homeostasis. Cytoplasmic pool of mRNA cap** enzyme …
Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion
E Orozco García, R Narváez Sánchez, MC Harmsen… - 2024 - bibliotecadigital.udea.edu.co
Background: The extracellular vesicles (EVs) secreted by adipose tissue-derived stromal
cells (ASC) are microenvironment modulators in tissue regeneration by releasing their …
cells (ASC) are microenvironment modulators in tissue regeneration by releasing their …