[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view

SM Kondengadan, S Bansal, C Yang, D Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

Imaging and editing the phospholipidome

DC Chiu, JM Baskin - Accounts of chemical research, 2022 - ACS Publications
Conspectus Membranes are multifunctional supramolecular assemblies that encapsulate
our cells and the organelles within them. Glycerophospholipids are the most abundant …

Bioorthogonal chemistry: Bridging chemistry, biology, and medicine

KM Hartung, EM Sletten - Chem, 2023 - cell.com
As chemical biologists sought methods to modify and study biomolecules in their native
environments, the need for bioorthogonal chemical reactions emerged. These fast and …

[HTML][HTML] Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism

M Tsuchiya, N Tachibana, K Nagao, T Tamura… - Cell Metabolism, 2023 - cell.com
Cellular lipid synthesis and transport are governed by intricate protein networks. Although
genetic screening should contribute to deciphering the regulatory networks of lipid …

Chemical tools for lipid cell biology

C Schultz - Accounts of chemical research, 2023 - ACS Publications
Conspectus Lipids are key components of all organisms. We are well educated in their use
as fuel and their essential role to form membranes. We also know much about their …

Chemical approaches for measuring and manipulating lipids at the organelle level

M Uematsu, JM Baskin - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
As the products of complex and often redundant metabolic pathways, lipids are challenging
to measure and perturb using genetic tools. Yet by virtue of being the major constituents of …

Synthetic Lipid Biology

PHB Chen, XL Li, JM Baskin - Chemical Reviews, 2025 - ACS Publications
Cells contain thousands of different lipids. Their rapid and redundant metabolism, dynamic
movement, and many interactions with other biomolecules have justly earned lipids a …

“Flash & Click”: Multifunctionalized Lipid Derivatives as Tools To Study Viral Infections

C Schultz, SE Farley, FG Tafesse - Journal of the American …, 2022 - ACS Publications
In this perspective article, we describe the current status of lipid tools for studying host lipid–
virus interactions at the cellular level. We discuss the potential lipidomic changes that viral …

Chemical biology tools for imaging-based analysis of organelle membranes and lipids

T Tamura, I Hamachi - Current Opinion in Chemical Biology, 2022 - Elsevier
Membrane biology studies have revealed that in addition to providing structural support for
compartment formation and membrane protein function, subcellular biomembranes are also …

Optogenetic Strategies for Optimizing the Performance of Phospholipids Biosensors

Y Yao, X Lou, L **, W Sun, J Liu, Y Chen… - Advanced …, 2024 - Wiley Online Library
High‐performance biosensors play a crucial role in elucidating the intricate spatiotemporal
regulatory roles and dynamics of membrane phospholipids. However, enhancing the …