Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
The inseparable relationship between cholesterol and hedgehog signaling
Ligands of the Hedgehog (HH) pathway are paracrine signaling molecules that coordinate
tissue development in metazoans. A remarkable feature of HH signaling is the repeated use …
tissue development in metazoans. A remarkable feature of HH signaling is the repeated use …
[HTML][HTML] Cytoneme signaling provides essential contributions to mammalian tissue patterning
During development, morphogens pattern tissues by instructing cell fate across long
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
Structural basis for catalyzed assembly of the Sonic hedgehog–Patched1 signaling complex
P Huang, BM Wierbowski, T Lian, C Chan… - Developmental cell, 2022 - cell.com
The dually lipidated Sonic hedgehog (SHH) morphogen signals through the tumor
suppressor membrane protein Patched1 (PTCH1) to activate the Hedgehog pathway, which …
suppressor membrane protein Patched1 (PTCH1) to activate the Hedgehog pathway, which …
Beyond energy and growth: the role of metabolism in developmental signaling, cell behavior and diapause
Metabolism is crucial for development through supporting cell growth, energy production,
establishing cell identity, developmental signaling and pattern formation. In many model …
establishing cell identity, developmental signaling and pattern formation. In many model …
Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy
Z Feng, S Zhu, W Li, M Yao, H Song… - European Journal of …, 2022 - Elsevier
The Hedgehog signaling pathway plays a vital role in embryonic development and tissue
patterning. Aberrant regulation of this pathway is commonly associated with the occurrence …
patterning. Aberrant regulation of this pathway is commonly associated with the occurrence …
Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins
K Ehring, SF Ehlers, J Froese, F Gude, J Puschmann… - Elife, 2024 - elifesciences.org
Abstract The Sonic hedgehog (Shh) signaling pathway controls embryonic development and
tissue homeostasis after birth. This requires regulated solubilization of dual-lipidated, firmly …
tissue homeostasis after birth. This requires regulated solubilization of dual-lipidated, firmly …
[HTML][HTML] DISP1 deficiency: Monoallelic and biallelic variants cause a spectrum of midline craniofacial malformations
A Lavillaureix, P Rollier, A Kim, V Panasenkava… - Genetics in …, 2024 - Elsevier
Purpose DISP1 encodes a transmembrane protein that regulates the secretion of the
morphogen, Sonic hedgehog, a deficiency of which is a major cause of holoprosencephaly …
morphogen, Sonic hedgehog, a deficiency of which is a major cause of holoprosencephaly …
Structural advances in sterol-sensing domain-containing proteins
The sterol-sensing domain (SSD) is present in several membrane proteins that function in
cholesterol metabolism, transport, and signaling. Recent progress in structural studies of …
cholesterol metabolism, transport, and signaling. Recent progress in structural studies of …
A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor
SF Ehlers, D Manikowski, G Steffes, K Ehring… - Journal of …, 2024 - mdpi.com
During their biosynthesis, Sonic hedgehog (Shh) morphogens are covalently modified by
cholesterol at the C-terminus and palmitate at the N-terminus. Although both lipids initially …
cholesterol at the C-terminus and palmitate at the N-terminus. Although both lipids initially …