We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …

To address the complexity of osteoarthritis, integration of multitissue analyses by multiomics
approaches with the inclusion of longitudinal clinical data is necessary for a comprehensive …

Background Knee osteoarthritis (KOA) characterized by degeneration of knee cartilage and
subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults …

Abstract Changes in potential regulatory elements are thought to be key drivers of
phenotypic divergence. However, identifying changes to regulatory elements that underlie …

The arrival of the Infinium DNA methylation BeadChips for mice and other nonhuman
mammalian species has outpaced the development of the informatics that supports their use …

Objective This review was designed to identify highlights of the osteoarthritis (OA) genetics
and epigenetics literature published between April 2017 and January 2018. Design A …

Objective The purpose of this review is to describe highlights from original research
publications related to osteoarthritis (OA), epigenetics and genomics with the intention of …

Phenotypic variation within the skeleton has biological, behavioral, and biomedical
functional implications for individuals and species. Thus, it is critical to understand how …

The evolution of complex skeletal traits in primates was likely influenced by both genetic and
environmental factors. Because skeletal tissues are notoriously challenging to study using …

Functional genomics research is continually improving our understanding of genotype-
phenotype relationships in humans, and comparative genomics perspectives can provide …