Synthetic alternatives to Matrigel

EA Aisenbrey, WL Murphy - Nature Reviews Materials, 2020 - nature.com
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Microparticles in contact with cells: from carriers to multifunctional tissue modulators

MD Neto, MB Oliveira, JF Mano - Trends in biotechnology, 2019 - cell.com
For several decades microparticles have been exclusively and extensively explored as
spherical drug delivery vehicles and large-scale cell expansion carriers. More recently …

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

SJ Mun, JS Ryu, MO Lee, YS Son, SJ Oh, HS Cho… - Journal of …, 2019 - Elsevier
Background & Aims The development of hepatic models capable of long-term expansion
with competent liver functionality is technically challenging in a personalized setting. Stem …

Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors

BS Borys, T Dang, T So, L Rohani, T Revay… - Stem Cell Research & …, 2021 - Springer
Background Human induced pluripotent stem cells (hiPSCs) hold enormous promise in
accelerating breakthroughs in understanding human development, drug screening, disease …

Induction and Maturation of Hepatocyte-Like Cells In Vitro: Focus on Technological Advances and Challenges

Y ** tissue is typically soft, highly hydrated, dynamic, and increasingly
heterogeneous matter. Recapitulating such characteristics in engineered cell‐instructive …

Sustained-release of PDGF from PLGA microsphere embedded thermo-sensitive hydrogel promoting wound healing by inhibiting autophagy

K Xu, N An, H Zhang, Q Zhang, K Zhang, X Hu… - Journal of Drug Delivery …, 2020 - Elsevier
Growth factors (GFs) act as important active molecules for the treatment of skin wounds.
However, their clinical translation is seriously restrained due to single function and short half …

Advanced biomaterials and processing methods for liver regeneration: state‐of‐the‐art and future trends

A da Silva Morais, S Vieira, X Zhao… - Advanced …, 2020 - Wiley Online Library
Liver diseases contribute markedly to the global burden of mortality and disease. The limited
organ disposal for orthotopic liver transplantation results in a continuing need for alternative …

Biomimetic mineralization of nanocrystalline hydroxyapatites on aminated modified polylactic acid microspheres to develop a novel drug delivery system for …

S Chen, R Guo, C **e, Q Liang, X **ao - Materials Science and …, 2020 - Elsevier
EPLA/nHAp composite microsphere, a novel drug delivery system potentially useful for the
local delivery of alendronate (AL) to bone tissue was developed via the biomimetic …

Modulation of reoviral cytolysis (II): cellular stemness

T Bourhill, L Rohani, M Kumar, P Bose, D Rancourt… - Viruses, 2023 - mdpi.com
Oncolytic viruses (OVs) are an emerging cancer therapeutic that are intended to act by
selectively targeting and lysing cancerous cells and by stimulating anti-tumour immune …