Blocking the Wnt/β-catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies

Y Chen, M Chen, K Deng - International journal of …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

[HTML][HTML] Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling

EMR Koelman, A Yeste-Vázquez… - Bioorganic & medicinal …, 2022 - Elsevier
The Wnt/β-catenin signaling pathway is crucially involved in embryonic development, stem
cell maintenance and tissue renewal. Hyperactivation of this pathway is associated with the …

[HTML][HTML] Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

A de Pellegars-Malhortie, L Picque Lasorsa, T Mazard… - Pharmaceuticals, 2024 - mdpi.com
Despite significant progress in cancer prevention, screening, and treatment, the still limited
number of therapeutic options is an obstacle towards increasing the cancer cure rate. In …

Recent advances of β-catenin small molecule inhibitors for cancer therapy: Current development and future perspectives

P Yang, Y Zhu, Q Zheng, S Meng, Y Wu… - European journal of …, 2022 - Elsevier
The Wnt/β-catenin signaling pathway is involved in many cellular physiological processes,
including embryonic development, cell proliferation and differentiation, tissue homeostasis …

Targeting Wnt/β-catenin signaling pathway in triple-negative breast cancer by benzylic organotrisulfides: Contribution of the released hydrogen sulfide towards potent …

D Bhattacherjee, K Raina, TK Mandal… - Free Radical Biology …, 2022 - Elsevier
The potent anti-cancer activity of naturally occurring organopolysulfides has attracted wide
research attention over the last two decades. Sustained donation of hydrogen sulfide (H 2 S) …

Combinatorial Effects of 5-Fluorouracil and Menadione on Wnt/β-Catenin Pathway in Human Colorectal Cancer Cells

VP Warrier, S Venkatachalam, R Sakthivel… - Applied Biochemistry …, 2025 - Springer
The incidence and mortality rates of colorectal cancer (CRC) are alarmingly high, and the
scientific community is consistently engaged in develo** newer therapeutic options for …

Uncovering potential diagnostic and pathophysiological roles of α‐synuclein and DJ‐1 in melanoma

A Quesnel, LD Martin, C Tarzi, VP Lenis… - Cancer …, 2024 - Wiley Online Library
Background Melanoma, the most lethal skin cancer type, occurs more frequently in
Parkinson's disease (PD), and PD is more frequent in melanoma patients, suggesting …

The Implication of Altered DKK1/LRP/β-catenin Signaling in Dexamethasone Induced Bone Remodeling Disruption: In Silico and In Vivo Studies in Male Rats

AM Maher, SR Saleh, DA Ghareeb, E Sheta… - … Academic Journal of …, 2024 - journals.ekb.eg
Background: Long-term glucocorticoid administration represents the main source of 2ry
osteoporosis, jeopardizing bone to fracture and loss. This study presents an innovation …

ARTICLE INFO ABSTRACT

SS Zaher, HH Abd El-Hady, N Khalifa - journals.ekb.eg
The present study was carried out to compare the normal aquaculture in earthen ponds and
the recirculating aquaculture system (RAS) in the overwintering of juvenile Nile tilapia …