Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …
Alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor PAC1: mechanisms of fine tuning of brain activity
J Blechman, G Levkowitz - Frontiers in endocrinology, 2013 - frontiersin.org
Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor
PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities …
PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities …
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the
cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has …
cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has …
Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its
role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP …
role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP …
Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis
T Seaborn, O Masmoudi-Kouli… - Current …, 2011 - benthamdirect.com
Apoptosis is a regulated process leading to cell death, which is implicated both in normal
development and in various pathologies including heart failure, stroke and …
development and in various pathologies including heart failure, stroke and …
Induction of neuronal differentiation of murine N2a cells by two polyphenols present in the mediterranean diet mimicking neurotrophins activities: resveratrol and …
In the prevention of neurodegeneration associated with aging and neurodegenerative
diseases (Alzheimer's disease, Parkinson's disease), neuronal differentiation is of interest. In …
diseases (Alzheimer's disease, Parkinson's disease), neuronal differentiation is of interest. In …
Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide
BD Armstrong, C Abad, S Chhith, G Cheung-Lau… - Neuroscience, 2008 - Elsevier
Peripheral nerve injury models are used to investigate processes that can potentially be
exploited in CNS injury. A consistent change that occurs in injured peripheral neurons is an …
exploited in CNS injury. A consistent change that occurs in injured peripheral neurons is an …
Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis
Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a widely expressed
neuropeptide originally discovered in the hypothalamus. It closely resembles vasoactive …
neuropeptide originally discovered in the hypothalamus. It closely resembles vasoactive …
[HTML][HTML] Effect of PACAP in central and peripheral nerve injuries
Pituitary adenylate cyclase activating polypeptide (PACAP) is a bioactive peptide with
diverse effects in the nervous system. In addition to its more classic role as a …
diverse effects in the nervous system. In addition to its more classic role as a …
Mechanisms of ethanol-induced death of cerebellar granule cells
J Luo - The Cerebellum, 2012 - Springer
Maternal ethanol exposure during pregnancy may cause fetal alcohol spectrum disorders
(FASD). FASD is the leading cause of mental retardation. The most deleterious effect of fetal …
(FASD). FASD is the leading cause of mental retardation. The most deleterious effect of fetal …