In this review we summarize the current understanding of signal transduction downstream of
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …

In the 30 years since its discovery, tyrosine phosphorylation has emerged as a
fundamentally important mechanism of signal transduction and regulation in all eukaryotic …

When properly employed, targeted therapies are effective cancer treatments. However, the
development of such therapies requires the identification of targetable drivers of cancer …

The analysis of proteome-wide phosphorylation events is still a major analytical challenge
because of the enormous complexity of protein phosphorylation networks. In this work, we …

Efficient cancer cell migration through tissue barriers requires dynamic interactions between
the ECM and the actin cytoskeleton as well as the capacity for matrix degradation (Wolf and …

Protein phosphorylation participates in the regulation of all fundamental biological
processes, and protein kinases have been intensively studied. However, while the focus …

The ability to conduct validated analyses of biomarkers is critically important in order to
establish the sensitivity and selectivity of the biomarker in identifying a particular disease …

Reversible protein phosphorylation serves as a basis for regulating a number of cellular
processes. Aberrant activation of kinase signaling pathways is commonly associated with …

Several mass spectrometry-based assays have emerged for the quantitative profiling of
cellular tyrosine phosphorylation. Ideally, these methods should reveal the exact sites of …

Despite the initial effectiveness of the tyrosine kinase inhibitor lapatinib against HER2 gene-
amplified breast cancers, most patients eventually relapse after treatment, implying that …