Cytokines function as communication tools of the immune system, serving critical functions
in many biological responses and sha** the immune response. When cytokine production …

The therapeutic armamentarium for management of inflammatory bowel diseases has
expanded dramatically in the last 5 years, with the introduction of several medications with …

METHODS: This single-center, double-blind, placebo-controlled trial randomized adult
patients with ASUC (defined by the Truelove Witts severity criteria) to receive either …

Introduction Most guidelines for IBD still recommend step-by-step therapy with initially
classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing …

The recent approval of new medications with novel mechanisms of action and emergence of
updated safety information for existing therapies has changed the treatment landscape of …

METHODS: We used data from a large, national commercial insurance plan in the United
States to identify patients 60 years and older with IBD who newly initiated tumor necrosis …

Background In the context of an ageing inflammatory bowel disease (IBD) population,
cardiovascular comorbidities become particularly relevant. Novel small molecule drugs …

Background & Aims This American Gastroenterological Association (AGA) living guideline is
intended to support practitioners in the pharmacological management of moderate-to-severe …

Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases
(ASCVD) in patients with chronic inflammatory disorders, particularly those afflicted with …

Abstract Background and Aims Tofacitinib (TFB) appears to be effective in the treatment of
ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB …