Microrobots for biomedicine: unsolved challenges and opportunities for translation

JG Lee, RR Raj, NB Day, CW Shields IV - ACS nano, 2023 - ACS Publications
Microrobots are being explored for biomedical applications, such as drug delivery, biological
cargo transport, and minimally invasive surgery. However, current efforts largely focus on …

Ultrasound-responsive matters for biomedical applications

D Huang, J Wang, C Song, Y Zhao - The Innovation, 2023 - cell.com
Ultrasound (US) is a biofavorable mechanical wave that has shown practical significance in
biomedical fields. Due to the cavitation effect, sonoluminescence, sonoporation, pyrolysis …

Ultrasound trap** and navigation of microrobots in the mouse brain vasculature

A Del Campo Fonseca, C Glück, J Droux… - Nature …, 2023 - nature.com
The intricate and delicate anatomy of the brain poses significant challenges for the treatment
of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in …

Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy

X Peng, S Tang, D Tang, D Zhou, Y Li, Q Chen… - Science …, 2023 - science.org
Nanorobotic manipulation to access subcellular organelles remains unmet due to the
challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as …

Urease-powered nanobots for radionuclide bladder cancer therapy

C Simó, M Serra-Casablancas, AC Hortelao… - Nature …, 2024 - nature.com
Bladder cancer treatment via intravesical drug administration achieves reasonable survival
rates but suffers from low therapeutic efficacy. To address the latter, self-propelled …

Acoustic microbubble propulsion, train-like assembly and cargo transport

J Janiak, Y Li, Y Ferry, AA Doinikov, D Ahmed - nature communications, 2023 - nature.com
Achieving controlled mobility of microparticles in viscous fluids can become pivotal in
biologics, biotechniques, and biomedical applications. The self-assembly, trap**, and …

A review on microrobots driven by optical and magnetic fields

Y Hou, H Wang, R Fu, X Wang, J Yu, S Zhang… - Lab on a Chip, 2023 - pubs.rsc.org
Due to their small sizes, microrobots are advantageous for accessing hard-to-reach spaces
for delivery and measurement. However, their small sizes also bring challenges in on-board …

Reduced rotational flows enable the translation of surface-rolling microrobots in confined spaces

U Bozuyuk, A Aghakhani, Y Alapan, M Yunusa… - Nature …, 2022 - nature.com
Biological microorganisms overcome the Brownian motion at low Reynolds numbers by
utilizing symmetry-breaking mechanisms. Inspired by them, various microrobot locomotion …

3D-printed micrometer-scale wireless magnetic cilia with metachronal programmability

S Zhang, X Hu, M Li, U Bozuyuk, R Zhang… - Science …, 2023 - science.org
Biological cilia play essential roles in self-propulsion, food capture, and cell transportation
by performing coordinated metachronal motions. Experimental studies to emulate the …

In vivo applications of micro/nanorobots

CM Oral, M Pumera - Nanoscale, 2023 - pubs.rsc.org
Untethered robots in the size range of micro/nano-scale offer unprecedented access to hard-
to-reach areas of the body. In these challenging environments, autonomous task completion …