Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

Microtubules composed of αβ-tubulin dimers are dynamic cytoskeletal polymers that play
key roles in essential cellular processes such as cell division, organelle positioning …

Tremendous progress has been made in understanding the functions of γ-tubulin and, in
particular, its role in microtubule nucleation since the publication of its discovery in 1989 …

The expression, cellular distribution, and subcellular sorting of the microtubule (MT)-
nucleating γ-tubulin small complex (γTuSC) proteins, GCP2 and GCP3, were studied in …

Abstract Keratin 19 (K19) belongs to the keratin family of proteins, which maintains structural
integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a …

The formation of the nuclear envelope and the subsequent compartmentalization of the
genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely …

Abstract Knowledge of γ-tubulin is increasing with regard to the cellular functions of this
protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in …

Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to
date have not been translated into effective therapy, necessitating pursuit of alternative …

Members of the tubulin superfamily are GTPases; the activities of GTPases are necessary for
life. The members of the tubulin superfamily are the constituents of the microtubules and the …

Tubulins in microtubules have been recognized as potential targets in cancer chemotherapy
for several years. However, their detection and imaging in living cells, especially following …