Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …
Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features
The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …
[HTML][HTML] Map** diversity in African trypanosomes using high resolution spatial proteomics
African trypanosomes are dixenous eukaryotic parasites that impose a significant human
and veterinary disease burden on sub-Saharan Africa. Diversity between species and life …
and veterinary disease burden on sub-Saharan Africa. Diversity between species and life …
Comprehensive sub-mitochondrial protein map of the parasitic protist Trypanosoma brucei defines critical features of organellar biology
We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …
Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation
The long slender bloodstream form Trypanosoma brucei maintains its essential
mitochondrial membrane potential (ΔΨm) through the proton-pum** activity of the FoF1 …
mitochondrial membrane potential (ΔΨm) through the proton-pum** activity of the FoF1 …
In vivo imaging with genetically encoded redox biosensors
AI Kostyuk, AS Panova, AD Kokova, DA Kotova… - International journal of …, 2020 - mdpi.com
Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …
both normal physiology and the pathogenesis of various diseases. However, this area of …
The convoluted history of haem biosynthesis
The capacity of haem to transfer electrons, bind diatomic gases, and catalyse various
biochemical reactions makes it one of the essential biomolecules on Earth and one that was …
biochemical reactions makes it one of the essential biomolecules on Earth and one that was …
The diverged trypanosome MICOS complex as a hub for mitochondrial cristae sha** and protein import
I Kaurov, M Vancová, B Schimanski, LR Cadena… - Current Biology, 2018 - cell.com
The mitochondrial contact site and cristae organization system (MICOS) is a multiprotein
complex responsible for cristae formation. Even though cristae are found in all mitochondria …
complex responsible for cristae formation. Even though cristae are found in all mitochondria …
Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed 'bifunctional'gRNA in mRNA …
J Meehan, SM McDermott, A Ivens… - Nucleic Acids …, 2023 - academic.oup.com
Abstract U-insertion/deletion (U-indel) RNA editing in trypanosome mitochondria is directed
by guide RNAs (gRNAs). This editing may developmentally control respiration in …
by guide RNAs (gRNAs). This editing may developmentally control respiration in …
Evolving differentiation in African trypanosomes
Differentiation is a central aspect of the parasite life cycle and encompasses adaptation to
both host and environment. If we accept that evolution cannot anticipate an organism's …
both host and environment. If we accept that evolution cannot anticipate an organism's …