Base excision repair and its implications to cancer therapy
Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
oxidative stress and in response to exogenous insults. The pathway is a coordinated …
Base excision repair: mechanisms and impact in biology, disease, and medicine
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …
single-base damage that appear to have minimal effects on the helix. Since its discovery in …
Signal-amplified detection of the tumor biomarker FEN1 based on cleavage-induced ligation of a dumbbell DNA probe and rolling circle amplification
B Li, A ** therapeutic agents targeting the DNA Damage Response
DM Wilson III, AM Deacon, MAJ Duncton… - Progress in biophysics …, 2021 - Elsevier
Cancer will directly affect the lives of over one-third of the population. The DNA Damage
Response (DDR) is an intricate system involving damage recognition, cell cycle regulation …
Response (DDR) is an intricate system involving damage recognition, cell cycle regulation …
A magnetic separation-assisted cascade hybridization chain reaction amplification strategy for sensitive detection of flap endonuclease 1
L Zhang, X Liu, N Zhang, X Liu, W Jiang - Sensors and Actuators B …, 2022 - Elsevier
Sensitive and accurate detection of flap endonuclease 1 (FEN1) is essential to understand
its roles in DNA replication and repair and explore its functions in tumor diagnosis and …
its roles in DNA replication and repair and explore its functions in tumor diagnosis and …
Fluorometric detection of cancer marker FEN1 based on double-flapped dumbbell DNA nanoprobe functionalized with silver nanoclusters
Abstract Flap endonuclease 1 (FEN1), a ubiquitous enzyme involved in DNA repair and
replication, is overexpressed in highly proliferative cancer cells. FEN1 has been recognized …
replication, is overexpressed in highly proliferative cancer cells. FEN1 has been recognized …
Label-free and homogeneous detection of flap endonuclease 1 by ligation-promoted hyperbranched rolling circle amplification platform
X Wei, Y Meng, Q Xu, J Hu, C Zhang - Talanta, 2022 - Elsevier
The structure-specific endonuclease FEN1 participates in various genome maintenance
pathways in eukaryotes and is associated with different human diseases. Herein, we …
pathways in eukaryotes and is associated with different human diseases. Herein, we …