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The microbiota-gut-brain axis: from motility to mood
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …
extrinsic factors influence signaling along this axis, modulating the function of both the …
[HTML][HTML] Tryptophan metabolism: a link between the gut microbiota and brain
The gut-brain axis (GBA) is a bilateral communication network between the gastrointestinal
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …
(GI) tract and the central nervous system. The essential amino acid tryptophan contributes to …
[HTML][HTML] Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome
The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI)
disorders. Determining its mechanistic role in disease has been difficult due to apparent …
disorders. Determining its mechanistic role in disease has been difficult due to apparent …
Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors
The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …
The intestinal epithelium: central coordinator of mucosal immunity
The gastrointestinal (GI) tract represents a unique challenge to the mammalian immune
system. It must tolerate the presence of the luminal microbiota and thus not respond to their …
system. It must tolerate the presence of the luminal microbiota and thus not respond to their …
Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …
an understanding of both the primary neurological injury and the secondary sequelae that …
Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism
The gut microbiota influences the health of the host, especially with regard to gut immune
homeostasis and the intestinal immune response. In addition to serving as a nutrient …
homeostasis and the intestinal immune response. In addition to serving as a nutrient …
Signals from the gut microbiota to distant organs in physiology and disease
The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is
fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived …
fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived …
Diet-induced extinctions in the gut microbiota compound over generations
The gut is home to trillions of microorganisms that have fundamental roles in many aspects
of human biology, including immune function and metabolism,. The reduced diversity of the …
of human biology, including immune function and metabolism,. The reduced diversity of the …
Regional diversity of the gastrointestinal microbiome
The role of gut microbes in health and disease has often been surmised from stool, which is
easily sampled and rich in microbial diversity, density, and abundance. Microbial analyses …
easily sampled and rich in microbial diversity, density, and abundance. Microbial analyses …