Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The …

Achieving good cell recovery after cryopreservation is an essential process when working
with induced pluripotent stem cells (iPSC). Optimized freezing and thawing methods are …

Abstract Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of
Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive …

Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …

Background Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B
(catB) are associated with increased risk of Parkinson's disease (PD). However, neither the …

Background Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent
tool in studying microglial function in health and disease. Yet, since differentiation and …

Mer tyrosine kinase (MerTK) is a receptor tyrosine kinase that mediates non-inflammatory,
homeostatic phagocytosis of diverse types of cellular debris. Highly expressed on the …

A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor
neurons (MNs) have been developed to investigate the underlying causes of selective MN …

The use of human derived induced pluripotent stem cells (hiPSCs) differentiated to
dopaminergic (DA) neurons offers a valuable experimental model to decorticate the cellular …

Amyotrophic lateral sclerosis (ALS) represents a complex neurodegenerative disorder with
significant genetic heterogeneity. To date, both the genetic etiology and the underlying …