Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

DP Veitch, MW Weiner, PS Aisen, LA Beckett… - Alzheimer's & …, 2019 - Elsevier
Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

Sleep quality and aging: a systematic review on healthy older people, mild cognitive impairment and Alzheimer's disease

M Casagrande, G Forte, F Favieri, I Corbo - International journal of …, 2022 - mdpi.com
Aging is characterized by changes in the structure and quality of sleep. When the alterations
in sleep become substantial, they can generate or accelerate cognitive decline, even in the …

Mild behavioral impairment is associated with atrophy of entorhinal cortex and hippocampus in a memory clinic cohort

V Matuskova, Z Ismail, T Nikolai, H Markova… - Frontiers in aging …, 2021 - frontiersin.org
Objectives Mild behavioral impairment (MBI) is a syndrome describing late-onset persistent
neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have …

Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals

FZ Lussier, TA Pascoal, M Chamoun… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Mild behavioral impairment (MBI) is characterized by the emergence of
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …

Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and …

Z Ismail, J Gatchel, DR Bateman… - International …, 2018 - cambridge.org
Background: Affective and emotional symptoms such as depression, anxiety, euphoria, and
irritability are common neuropsychiatric symptoms (NPS) in pre-dementia and cognitively …

Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: a …

MA Maito, H Santamaría-García… - The Lancet Regional …, 2023 - thelancet.com
Background Global brain health initiatives call for improving methods for the diagnosis of
Alzheimer's disease (AD) and frontotemporal dementia (FTD) in underrepresented …

Using machine learning to predict dementia from neuropsychiatric symptom and neuroimaging data

S Gill, P Mouches, S Hu, D Rajashekar… - Journal of …, 2020 - content.iospress.com
Background: Machine learning (ML) is a promising technique for patient-specific prediction
of mild cognitive impairment (MCI) and dementia development. Neuropsychiatric symptoms …

Assessing mild behavioral impairment with the mild behavioral impairment-checklist in people with mild cognitive impairment

SC Mallo, Z Ismail, AX Pereiro, D Facal… - Journal of …, 2018 - content.iospress.com
Background: Neuropsychiatric symptoms (NPS) are non-cognitive, behavioral, or psychiatric
symptoms, common in mild cognitive impairment (MCI) and associated with a higher risk of …

The implications of different approaches to define AT (N) in Alzheimer disease

N Mattsson-Carlgren, A Leuzy, S Janelidze… - Neurology, 2020 - AAN Enterprises
Objective To compare different β-amyloid (Aβ), tau, and neurodegeneration (AT [N]) variants
within the Swedish BioFINDER studies. Methods A total of 490 participants were classified …

Neural correlates of the impulse dyscontrol domain of mild behavioral impairment

S Gill, M Wang, P Mouches… - … Journal of Geriatric …, 2021 - Wiley Online Library
Objectives Agitation and aggression are common in dementia and pre‐dementia. The
dementia risk syndrome mild behavioral impairment (MBI) includes these symptoms in the …