Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism

S Badawy, YQ Yang, Y Liu, MA Marawan… - Critical Reviews in …, 2021 - Taylor & Francis
Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …

Application of PK/PD modeling in veterinary field: dose optimization and drug resistance prediction

I Ahmad, L Huang, H Hao, P Sanders… - BioMed research …, 2016 - Wiley Online Library
Among veterinary drugs, antibiotics are frequently used. The true mean of antibiotic
treatment is to administer dose of drug that will have enough high possibility of attaining the …

The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium

J Li, H Hao, G Cheng, X Wang, S Ahmed… - Scientific reports, 2017 - nature.com
To investigate the optimal dosage which can improve clinical efficacy and minimize
resistance, pharmacokinetics/pharmacodynamics model of enrofloxacin was established …

Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle

I Ahmad, H Hao, L Huang, P Sanders, X Wang… - Frontiers in …, 2015 - frontiersin.org
Cefquinome is a fourth generation cephalosporin with antimicrobial activity against gram
negative and gram positive bacterial species, including Staphylococcus aureus. The aim of …

Enrofloxacin dose optimization for the treatment of colibacillosis in broiler chickens using a drinking behaviour pharmacokinetic model

R Temmerman, L Pelligand, W Schelstraete… - Antibiotics, 2021 - mdpi.com
Enrofloxacin is frequently administered via drinking water for the treatment of colibacillosis in
broiler chickens. However, the EMA/CVMP has urged to re-evaluate historically approved …

Pharmacokinetics of Enrofloxacin in Plasma, Urine, and Feces of Donkey (Equus asinus) after a Single Intragastric Administration

B Yang, S Liu, J Cheng, H Qu, Y Guo, C Ji, Y Wang… - Antibiotics, 2024 - mdpi.com
Enrofloxacin is a broad-spectrum antimicrobial agent, but the study of its pharmacokinetics/
pharmacodynamics (PKs/PDs) in donkeys is rarely reported. The present study aimed to …

Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents

W Luo, D Chen, M Wu, Z Li, Y Tao… - Journal of …, 2019 - synapse.koreamed.org
Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in
bacterial resistance, clinical treatment failure, and drug residues. To address these …

Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling

X Liu, Q Yang, Y Fan, Y Du, L Lei, D Wang… - BMC Veterinary …, 2021 - Springer
Background Enrofloxacin is an antibacterial drug with broad-spectrum activity that is widely
indicated for veterinary use. We aim to develop the clinical applications of Enrofloxacin …

Pharmacokinetic–Pharmacodynamic Modeling of Enrofloxacin Against Escherichia coli in Broilers

KN Sang, HH Hao, LL Huang, X Wang… - Frontiers in veterinary …, 2016 - frontiersin.org
The purpose of the present study was to establish a pharmacokinetic/pharmacodynamic
(PK/PD) modeling approach for the dosage schedule design and decreasing the emergence …

Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous …

JW Kang, MA Hossain, H Park… - Journal of …, 2019 - synapse.koreamed.org
It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to
attain clinical success. We undertook this study to optimize the dose of enrofloxacin against …