The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

The history of drug metabolism began in the 19th Century and developed slowly. In the mid-
20th Century the relationship between drug metabolism and toxicity became appreciated …

The field of cytochrome P450 (P450) research has developed considerably over the past 20
years, and many important papers on the roles of P450s in chemical toxicology have …

An overview is presented on the molecular aspects of toxicity due to paracetamol
(acetaminophen) and structural analogues. The emphasis is on four main topics, that is …

Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …

Drug-induced liver injury is an important clinical problem and a challenge for drug
development. Whereas progress in understanding rare and unpredictable (idiosyncratic) …

Cytochromes P450 are responsible for metabolism of most xenobiotics and are required for
the efficient elimination of foreign chemicals from the body. Paradoxically, these enzymes …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …