During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Recent developments on particle formation from polymers using supercritical fluids have
been reviewed with an emphasis on articles published during 2000–2003. First, a brief …

Written at a level comprehensible to non-experts, this handbook covers the current state of
encapsulation and controlled released technologies, presenting the fundamental processes …

Cyclodextrins (CDs) are a family of cyclic oligosaccharides with a hydrophilic outer surface
and a lipophilic central cavity. CD molecules are relatively large with a number of hydrogen …

Literature data are reviewed on the properties of ibuprofen related to the biopharmaceutics
classification system (BCS). Ibuprofen was assessed to be a BCS class II drug. Differences …

The interest of the use of supercritical fluids, especially supercritical CO2, for particle
engineering over the last years has received attention from the pharmaceutical industry …

Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to
reach market due to their poor aqueous solubility. For orally administered drugs solubility is …

Supercritical fluids possess the unique properties of behaving like liquids and gases, above
their critical point. Supercritical fluid technology has recently emerged as a green and novel …

In the present study, the practically insoluble drug, simvastatin (SV), and its inclusion
complex with hydroxypropyl β-cyclodextrin (HP-β-CD) prepared using supercritical …

Recent developments in biodegradable particle formation using supercritical fluids and
dense gases have been reviewed with an emphasis on studies of micronizing and …