The past several years have witnessed a rapidly increasing number of reports on utilizing
plasmid DNA as a vector for the introduction of genes into mammalian cells for use in both …

This review focuses on DNA vaccines, denoting the last two decades since the early
substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In …

Despite the development of highly effective prophylactic vaccines against human
papillomavirus (HPV) serotypes 16 and 18, prevention of cervical dysplasia and cancer in …

This work demonstrates that electrical muscle stimulation markedly increases the
transfection efficiency of an intramuscular injection of plasmid DNA. In soleus or extensor …

Novel tuberculosis DNA vaccines encoding native ESAT-6, MPT-64, KatG, or HBHA
mycobacterial proteins or the same proteins fused to tissue plasminogen activator (TPA) …

Immunization with nucleic acids has been shown to induce both antigen‐specific cellular
and humoral immune responses in vivo. We hypothesize that immunization with DNA could …

A novel strategy achieved the eradication of lung tumor metastases by joint suppression of
angiogenesis in the tumor neovasculature and induction of tumor cell apoptosis. This was …

Great progress has been made with respect to our understanding of the
immunopathogenesis of AIDS and the infectious agent, HIV, that causes the disease. HIV, a …

The most effective mechanism for the elimination of disease from society is the use of
vaccinations, but these often require repeated administration. However, single …

Background DNA vaccines are a promising approach to vaccination since they circumvent
the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown …