Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation

F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …

Cognitive contributions to gait and falls: evidence and implications

M Amboni, P Barone, JM Hausdorff - Movement disorders, 2013 - Wiley Online Library
Dementia and gait impairments often coexist in older adults and patients with
neurodegenerative disease. Both conditions represent independent risk factors for falls. The …

Characterizing freezing of gait in Parkinson's disease: models of an episodic phenomenon

A Nieuwboer, N Giladi - Movement Disorders, 2013 - Wiley Online Library
Freezing of gait (FOG) is a very disabling and common gait disorder in Parkinson's disease
(PD). The first aim of this article was to provide a methodological and critical review of the …

Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson's disease

JM Shine, E Matar, PB Ward, SJ Bolitho, M Gilat… - Brain, 2013 - academic.oup.com
Freezing of gait is a devastating symptom of advanced Parkinson's disease yet the neural
correlates of this phenomenon remain poorly understood. In this study, severity of freezing of …

Cognition and freezing of gait in Parkinson's disease: A systematic review and meta-analysis

AS Monaghan, E Gordon, L Graham, E Hughes… - Neuroscience & …, 2023 - Elsevier
Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's
Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a …

Ocular and visual disorders in Parkinson's disease: common but frequently overlooked

MS Ekker, S Janssen, K Seppi, W Poewe… - Parkinsonism & related …, 2017 - Elsevier
Patients with Parkinson's disease (PD) often compensate for their motor deficits by guiding
their movements visually. A wide range of ocular and visual disorders threatens the patients' …

Freezing of gait in Parkinson's disease: where are we now?

E Heremans, A Nieuwboer, S Vercruysse - Current neurology and …, 2013 - Springer
Freezing of gait (FOG) is defined as a brief, episodic absence or marked reduction of forward
progression of the feet despite the intention to walk. It is one of the most debilitating motor …

[HTML][HTML] Visual dysfunction in Parkinson's disease

F Nieto-Escamez, E Obrero-Gaitán, I Cortés-Pérez - Brain Sciences, 2023 - mdpi.com
Non-motor symptoms in Parkinson's disease (PD) include ocular, visuoperceptive, and
visuospatial impairments, which can occur as a result of the underlying neurodegenerative …

The next step: a common neural mechanism for freezing of gait

SJG Lewis, JM Shine - The Neuroscientist, 2016 - journals.sagepub.com
Freezing of gait is a disabling symptom of Parkinson's disease that causes a paroxysmal
cessation of normal footsteps while walking. Despite a great deal of empirical research, the …

Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease

VE Kelly, CO Johnson, EL McGough… - Parkinsonism & related …, 2015 - Elsevier
Introduction Research suggests an association between global cognition and postural
instability/gait disturbance (PIGD) in Parkinson disease (PD), but the relationship between …