Age-related macular degeneration (AMD) is the predominant cause of visual loss in old
people in the developed world, whose incidence is increasing. This disease is caused by …

Retinal pigment epithelium (RPE) are specialized, multifunctional cells in the retina that form
a monolayer of cuboidal, polarized cells adjoining the photoreceptor cells. The RPE are a …

Constant or intense light degenerates the retina and retinal pigment epithelial cells. Light
generates reactive oxygen species and nitric oxide leading to initial reactions of retinal …

Purpose The current study aims to determine the molecular mechanisms of diabetic
retinopathy (DR) using the protein-protein interactome and metabolome map. We examined …

Disruption of the mitochondrial-nuclear network leads to accelerated aging and agerelated
diseases, including age-related macular degeneration. The current study tested the …

In the current study, we suggest that phosphorylation reactions of specific proteins in
mitochondria and the nucleus are a key step in the progression of age-related macular …