Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles

A Forigua, RL Kirsch, SM Willerth, KS Elvira - Journal of Controlled Release, 2021 - Elsevier
Drug releasing particles are valued for their ability to deliver therapeutics to targeted
locations and for their controllable release patterns. The development of microfluidic …

A comprehensive review of one decade of microfluidic platforms applications in synthesis of enhanced carriers utilized in controlled drug delivery

S Siavashy, M Soltani, M Ahmadi… - Advanced Materials …, 2022 - Wiley Online Library
Novel nanocarriers such as multifunctional nanoparticles (NPs) have recently attracted
attention due to their various applications, specifically in medicine and treatment. However, it …

Optimization of an injectable hydrogel depot system for the controlled release of retinal-targeted hybrid nanoparticles

I Ottonelli, A Bighinati, E Adani, F Loll, R Caraffi… - Pharmaceutics, 2022 - mdpi.com
A drawback in the development of treatments that can reach the retina is the presence of
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …

[HTML][HTML] Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved …

W Pei, L Cai, X Gong, L Zhang, J Zhang, P Zhu… - Materials Today Bio, 2022 - Elsevier
Despite its prominent therapeutic efficacy, chemotherapy has raised serious concerns due to
the severe adverse effects and multidrug resistance evoked, which propels the search for …

In vivo evaluation of time-dependent antithrombotic effect of rivaroxaban-loaded poly (lactic-co-glycolic acid)/sodium lauryl sulfate or didodecyl dimethylammonium …

P de Souza Furtado, AASC de Oliveira… - European Journal of …, 2023 - Elsevier
Rivaroxaban (RVX), an oral direct factor Xa inhibitor, is being explored as an alternative to
traditional anticoagulans. However, RVX still faces pharmacokinetic limitations and adverse …

Vancomycin-loaded nanoparticles against vancomycin intermediate and methicillin resistant Staphylococcus aureus strains

A Simon, MLA Moreira, IFJB Costa… - …, 2020 - iopscience.iop.org
Bacterial infections represent one of the leading causes of mortality in the world. Among
causative pathogens, S. aureus is prominently known as the underlying cause of many …

Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials

MM Mahmud, N Pandey, JA Winkles, GF Woodworth… - Nano Today, 2024 - Elsevier
Nanotherapeutics have gained significant attention for the treatment of numerous cancers,
primarily because they can accumulate in and/or selectively target tumors leading to …

Lipase‐Responsive Rifampicin‐Based Biodegradable PCL Nanocarrier for Antibacterial Treatment

E Osehontue Uroro, R Bright, J Yang Quek… - …, 2023 - Wiley Online Library
Rifampicin (RFP) is a first‐line drug used to treat a variety of infections, including wound
infections but has limitations in its use due to its toxicity. Hence, an urgent need exists for the …

The roadmap to micro: Generation of micron‐sized polymeric particles using a commercial microfluidic system

M Cruz‐Acuña, H Kakwere… - Journal of Biomedical …, 2022 - Wiley Online Library
Microfluidic‐assisted particle fabrication provides a route to circumvent the disadvantages
associated with traditional methods of polymeric particle generation, such as low drug …

Advanced Nanotechnologies for the Central Nervous System: design, Optimization, Application, and Scale-up

I Ottonelli - 2023 - theses.hal.science
Nanotechnologies, such as nanoparticles (NPs) and nanomedicines (NMeds), show great
promise for treating and diagnosing central nervous system diseases due to features like …