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B cell targeted therapies in inflammatory autoimmune disease of the central nervous system
Cumulative evidence along several lines indicates that B cells play an important role in the
pathological course of multiple sclerosis (MS), neuromyelitisoptica spectrum disorders …
pathological course of multiple sclerosis (MS), neuromyelitisoptica spectrum disorders …
Decoding physiological and pathological roles of innate immune cells in eye diseases: the perspectives from single-cell RNA sequencing
C Lu, X Mao, S Yuan - Frontiers in Immunology, 2024 - frontiersin.org
Single-cell RNA sequencing (scRNA-seq) has facilitated a deeper comprehension of the
molecular mechanisms behind eye diseases and has prompted the selection of precise …
molecular mechanisms behind eye diseases and has prompted the selection of precise …
Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis
While neurodegeneration underlies the pathological basis for permanent disability in
multiple sclerosis (MS), predictive biomarkers for progression are lacking. Using an animal …
multiple sclerosis (MS), predictive biomarkers for progression are lacking. Using an animal …
Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration
Background Retinal degeneration is a disease affecting the eye, which is an immune-
privileged site because of its anatomical and physiological properties. Alterations in retinal …
privileged site because of its anatomical and physiological properties. Alterations in retinal …
Retinal hyperreflecting foci associate with cortical pathology in multiple sclerosis
M Pengo, S Miante, S Franciotta… - Neurology …, 2022 - neurology.org
Background and Objectives Microglia, the resident immune cell of the brain and retina, is
widespread activated in the white and gray matter (GM) in multiple sclerosis (MS). The …
widespread activated in the white and gray matter (GM) in multiple sclerosis (MS). The …
Retinal transcriptome profiling identifies novel candidate genes associated with visual impairment in a mouse model of multiple sclerosis
Visual impairment is occasionally observed in multiple sclerosis (MS) and its animal model,
experimental autoimmune encephalomyelitis (EAE). Although uveitis and optic neuritis have …
experimental autoimmune encephalomyelitis (EAE). Although uveitis and optic neuritis have …
Proteomics analyses of small extracellular vesicles of aqueous humor: identification and validation of GAS6 and SPP1 as glaucoma markers
Cataracts and glaucoma account for a high percentage of vision loss and blindness
worldwide. Small extracellular vesicles (sEVs) are released into different body fluids …
worldwide. Small extracellular vesicles (sEVs) are released into different body fluids …
Utility of the visual system to monitor neurodegeneration in multiple sclerosis
GM Mey, TM DeSilva - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Neurodegeneration occurs early in the multiple sclerosis (MS) disease course and is an
important driver of permanent disability. Current immunomodulatory therapies do not directly …
important driver of permanent disability. Current immunomodulatory therapies do not directly …
Delimiting MOGAD as a disease entity using translational imaging
The first formal consensus diagnostic criteria for myelin oligodendrocyte glycoprotein
antibody-associated disease (MOGAD) were recently proposed. Yet, the distinction of …
antibody-associated disease (MOGAD) were recently proposed. Yet, the distinction of …
Non-invasive in vivo imaging of brain and retinal microglia in neurodegenerative diseases
Microglia play crucial roles in immune responses and contribute to fundamental biological
processes within the central nervous system (CNS). In neurodegenerative diseases …
processes within the central nervous system (CNS). In neurodegenerative diseases …