DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a
key role in human adrenal and reproductive development. Loss of DAX-1 function is …

Sex steroids are crucial regulators of sexual differentiation and the proper development of
secondary sex characteristics and patterns of sexual behavior. Since Leydig cells are the …

Context: Primary adrenal failure is a life-threatening condition that can be caused by a range
of etiologies, including autoimmune, metabolic, and developmental disorders. The nuclear …

The foetal Leydig cell population arises shortly after testicular differentiation at around 12.5
dpc in the mouse and 6 weeks in the human. These cells function, primarily, to produce …

Precocious puberty is defined as the development of secondary sexual characteristics
before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious …

Puberty is the stage of growth leading to sexual maturity and reproductive capacity. In girls,
the initial physical changes are breast development; in boys, testicular growth—both …

Objective Nicotinamide nucleotide transhydrogenase (NNT), one of the several genes
recently discovered in familial glucocorticoid deficiencies (FGD), is involved in reactive …

Adult Leydig cell steroidogenesis is dependent on LH but fetal Leydig cells can function
independently of gonadotropin stimulation. To identify factors that may be involved in …

Mutations in DAX1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC)
critical region on the X chromosome gene 1; NR0B1] cause X-linked AHC, a disease …

DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X,
gene 1; also known as NROB1, nuclear receptor subfamily 0, group B, member 1) encodes …