Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Host–microbiota maladaptation in colorectal cancer

A Janney, F Powrie, EH Mann - Nature, 2020 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Metabolic communication by SGLT2 inhibition

AM Billing, YC Kim, S Gullaksen, B Schrage, J Raabe… - Circulation, 2024 - ahajournals.org
BACKGROUND: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect
the kidneys and heart, but the underlying mechanism remains poorly understood …

The astounding exhaustiveness and speed of the Astral mass analyzer for highly complex samples is a quantum leap in the functional analysis of microbiomes

T Dumas, R Martinez Pinna, C Lozano, S Radau… - Microbiome, 2024 - Springer
Background By analyzing the proteins which are the workhorses of biological systems,
metaproteomics allows us to list the taxa present in any microbiota, monitor their relative …

Metaproteomics to understand how microbiota function: The crystal ball predicts a promising future

J Armengaud - Environmental Microbiology, 2023 - Wiley Online Library
In the medical, environmental, and biotechnological fields, microbial communities have
attracted much attention due to their roles and numerous possible applications. The study of …

Challenges and future directions for studying effects of host genetics on the gut microbiome

S Sanna, A Kurilshikov, A van der Graaf, J Fu… - Nature …, 2022 - nature.com
The human gut microbiome is a complex ecosystem that is involved in its host's metabolism,
immunity and health. Although interindividual variations in gut microbial composition are …

Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics

D Gómez-Varela, F **an, S Grundtner… - Frontiers in …, 2023 - frontiersin.org
Introduction Metaproteomics is a rapidly advancing field that offers unique insights into the
taxonomic composition and the functional activity of microbial communities, and their effects …

Five key aspects of metaproteomics as a tool to understand functional interactions in host associated microbiomes

F Salvato, RL Hettich, M Kleiner - Advances in Clinical …, 2021 - taylorfrancis.com
Host-associated microbial communities (microbiomes) play critical roles in human, animal,
and plant health and development. Basic metaproteomes can provide diverse types of …

A comprehensive overview of microbiome data in the light of machine learning applications: categorization, accessibility, and future directions

B Kumar, E Lorusso, B Fosso, G Pesole - Frontiers in microbiology, 2024 - frontiersin.org
Metagenomics, Metabolomics, and Metaproteomics have significantly advanced our
knowledge of microbial communities by providing culture-independent insights into their …

[HTML][HTML] The landscape and perspectives of the human gut metaproteomics

Z Sun, Z Ning, D Figeys - Molecular & Cellular Proteomics, 2024 - Elsevier
The human gut microbiome is closely associated with human health and diseases.
Metaproteomics has emerged as a valuable tool for studying the functionality of the gut …