HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome.
The provirus can then either actively transcribe RNA or enter a latent state, without viral …

Pulmonary vascular disease, including pulmonary arterial hypertension (PAH), is
increasingly recognized to be affected by systemic alterations including up‐regulation of the …

Partial endothelial-to-mesenchymal transition (EndMT) is an intermediate phenotype
observed in endothelial cells (ECs) undergoing a transition toward a mesenchymal state to …

Abstract Intronic GGGGCC (G4C2) hexanucleotide repeat expansion within the human
C9orf72 gene represents the most common cause of familial forms of amyotrophic lateral …

Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and
complications of cirrhosis by antagonizing the mineralocorticoid receptor. However, SP also …

Human immunodeficiency virus (HIV) transcription requires assembly of cellular
transcription factors at the human immunodeficiency virus type 1 (HIV-1) promoter. The TFIIH …

Simple Summary In the elderly population, it is important to find the right anti-inflammatory
and pro-inflammatory balance to avoid the impairment of the immune system, which …

Pulmonary arterial hypertension (PAH) is a progressive condition that frequently leads to
right ventricular (RV) remodeling. Aldosterone promotes vascular and RV remodeling. The …

UVB wavelengths of light induce the formation of photoproducts in genomic DNA that are
potentially mutagenic and detrimental to epidermal cell function. The mineralocorticoid and …

Pulmonary hypertension (PH) is a devastating condition characterized by pulmonary
vascular remodelling, leading to progressive increase in pulmonary artery pressure and …