Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

The small intestine: dining table of host–microbiota meetings

K Delbaere, I Roegiers, A Bron, C Durif… - FEMS Microbiology …, 2023 - academic.oup.com
Growing evidence suggests the importance of the small intestinal bacteria in the diet–host–
microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly …

Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome

Y Zhang, S Zhang, B Li, Y Luo, Y Gong… - Cardiovascular …, 2022 - academic.oup.com
Aims Ageing is the most significant contributor to the increasing prevalence of atrial
fibrillation (AF). The gut microbiota dysbiosis is involved in age-related diseases. However …

Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis

F Bishehsari, PA Engen, NZ Preite, YE Tuncil, A Naqib… - Genes, 2018 - mdpi.com
Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC).
One possible mechanism of fiber is its fermentation property in the gut and ability to change …

[HTML][HTML] APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

TTT Tran, S Corsini, L Kellingray, C Hegarty… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for
Alzheimer's disease (AD). Numerous studies have provided insights into the pathologic …

[HTML][HTML] The microbiome: an emerging key player in aging and longevity

M Kim, BA Benayoun - Translational medicine of aging, 2020 - Elsevier
Revolutionary advancements of high-throughput sequencing and metagenomic tools have
provided new insights to microbiome function, including a bidirectional relationship between …

The Ramazzini Institute 13-week pilot study on glyphosate and Roundup administered at human-equivalent dose to Sprague Dawley rats: effects on the microbiome

Q Mao, F Manservisi, S Panzacchi, D Mandrioli… - Environmental …, 2018 - Springer
Abstract Background Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides
that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs …

The gut microbiome and aquatic toxicology: an emerging concept for environmental health

O Adamovsky, AN Buerger… - Environmental …, 2018 - Wiley Online Library
The microbiome plays an essential role in the health and onset of diseases in all animals,
including humans. The microbiome has emerged as a central theme in environmental …

Effects of anti-aging interventions on intestinal microbiota

Y Du, Y Gao, B Zeng, X Fan, D Yang, M Yang - Gut Microbes, 2021 - Taylor & Francis
Identifying ways to deal with the challenges presented by aging is an urgent task, as we are
facing an aging society. External factors such as diet, exercise and drug therapy have …

[HTML][HTML] Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences

P Gabarre, C Loens, Y Tamzali, B Barrou… - American Journal of …, 2022 - Elsevier
Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …