Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …
Up-down regulation of HIF-1α in cancer progression
Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
B Yue, C Song, L Yang, R Cui, X Cheng, Z Zhang… - Molecular cancer, 2019 - Springer
Background As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
Hallmarks of cancer—the new testament
Ancient Egyptians believed cancer to be a curse, as seen from evidence as old as 3000 BC
from the Edwin Smith Papyrus which described breast cancer and Ebers Papyrus dated …
from the Edwin Smith Papyrus which described breast cancer and Ebers Papyrus dated …
[HTML][HTML] β-Sitosterol as a promising anticancer agent for chemoprevention and chemotherapy: mechanisms of action and future prospects
H Wang, Z Wang, Z Zhang, J Liu, L Hong - Advances in Nutrition, 2023 - Elsevier
Cancer is one of the primary causes of death worldwide, and its incidence continues to
increase yearly. Despite significant advances in research, the search for effective and …
increase yearly. Despite significant advances in research, the search for effective and …
Context-dependent EMT programs in cancer metastasis
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
HDACs and HDAC inhibitors in cancer development and therapy
Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …
Cancer metastasis: molecular mechanisms and clinical perspectives
Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …
shapes the course of disease for cancer patients and commonly determines its lethal …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and
resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like …
resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like …