The role of inflammation in Alzheimer's disease

EE Tuppo, HR Arias - The international journal of biochemistry & cell …, 2005 - Elsevier
Considerable evidence gained over the past decade has supported the conclusion that
neuroinflammation is associated with Alzheimer's disease (AD) pathology. Inflammatory …

Human gut microbiota: the links with dementia development

R Alkasir, J Li, X Li, M **, B Zhu - Protein & cell, 2017 - academic.oup.com
Dementia is a comprehensive category of brain diseases that is great enough to affect a
person's daily functioning. The most common type of dementia is Alzheimer's disease, which …

Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

B Ding, C Lin, Q Liu, Y He, JB Ruganzu, H **… - Journal of …, 2020 - Springer
Background Glial activation and neuroinflammation play a crucial role in the pathogenesis
and development of Alzheimer's disease (AD). The receptor for advanced glycation end …

[HTML][HTML] Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

MV Guillot-Sestier, KR Doty, D Gate, J Rodriguez… - Neuron, 2015 - cell.com
The impact of inflammation suppressor pathways on Alzheimer's disease (AD) evolution
remains poorly understood. Human genetic evidence suggests involvement of the cardinal …

Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis

E Bagyinszky, V Van Giau, K Shim, K Suk… - Journal of the …, 2017 - Elsevier
Alzheimer's disease (AD) is a complex disorder and the most common form of
neurodegenerative dementia. Several genetic, environmental, and physiological factors …

The muscle-brain axis and neurodegenerative diseases: the key role of mitochondria in exercise-induced neuroprotection

J Burtscher, GP Millet, N Place, B Kayser… - International Journal of …, 2021 - mdpi.com
Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis

GAW Rook - Immunology, 2009 - Wiley Online Library
Man has moved rapidly from the hunter–gatherer environment to the living conditions of the
rich industrialized countries. The hygiene hypothesis suggests that the resulting changed …

Novel Alzheimer's disease genes and epistasis identified using machine learning GWAS platform

M Lundberg, LMF Sng, P Szul, R Dunne, A Bayat… - Scientific Reports, 2023 - nature.com
Alzheimer's disease (AD) is a complex genetic disease, and variants identified through
genome-wide association studies (GWAS) explain only part of its heritability. Epistasis has …

[HTML][HTML] Association between periodontitis and Alzheimer's disease

K Abbayya, NY Puthanakar… - … American journal of …, 2015 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with
age. Its onset can be either early or late. AD is characterized by the salient inflammatory …

Periodontitis Induced by P. gingivalis-LPS Is Associated With Neuroinflammation and Learning and Memory Impairment in Sprague-Dawley Rats

Y Hu, H Li, J Zhang, X Zhang, X **a, C Qiu… - Frontiers in …, 2020 - frontiersin.org
Background Periodontitis is one of the most common oral diseases and is a potential risk
factor for systemic diseases. In this study, we aimed to investigate the association between …