Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in
the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin …

Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It
remains an important and effective therapy in many forms of cancer today. Cisplatin …

Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …

Cisplatin is one of the most widely used and most potent chemotherapy drugs. However,
side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use …

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by
conducting different omics data analyses, we demonstrated that cisplatin induces cell death …

Cisplatin is a highly effective antitumor agent whose clinical application is limited by the
inherent nephrotoxicity. The current measures of nephroprotection used in patients receiving …

Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-
weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first …

cis-Diamminedichloroplatinum (II)(cisplatin) is an important chemotherapeutic agent useful
in the treatment of several cancers; however, it has several side effects such as …

Naproxen is a common analgesic and antipyretic medication that is widely used around the
world. This medicine at high doses leads to liver and kidney necrosis in humans and …